Type I vs Type II MI discrimination

Every molecule scored on five evidence-anchored axes and a composite Type-I Discrimination Index (T1DI). All non-null scores trace to PubMed references; absence of evidence is shown as —, never as zero. Sort by any column. Click a row for the molecule's full evidence page.

Evidence is abstract-level. Scores are mined from PubMed abstracts, so a cited study may be topically relevant to a marker without directly testing the Type-1-vs-Type-2 comparison stated. Treat this as a hypothesis-generating map, not adjudicated diagnostic evidence.

1,948

molecules scored

325

deep-scored (Tier 1)

full abstract extraction

117

with rupture (R) evidence

270

with confounder (C) evidence

direct T1-vs-T2 studies

head-to-head

The 6 markers with direct head-to-head evidence

The strongest tier — studies that directly compare the marker between Type-I and Type-II MI patients. Green = higher in Type I; orange = higher in Type II.

Cardiac troponin I↑ Type I

hs-cTnI: 1.4 ± 5.1 ng/L in T1MI vs 0.5 ± 1.1 ng/L in T2MI (P = 0.030)

T1DI 62 · 13 refs · Shared / rises in both

CK-MB↑ Type I

CK-MB levels/rises were higher in Type-1 MI compared to Type-2 MI patients in studies directly comparing the two groups.

T1DI 67.5 · 17 refs · Shared / rises in both

Copeptin↑ Type I

Copeptin levels were significantly elevated in T1MI compared to T2MI patients, supporting differentiation between the two MI types.

T1DI 23.3 · 19 refs · Shared / rises in both

Cardiac Myosin-Binding Protein C↑ Type I

cMyBP-C levels measured in both T1MI and T2MI cohorts; higher discrimination value for T1MI vs T2MI when combined with other biomarkers.

T1DI 25.5 · 7 refs · Shared / rises in both

Apolipoprotein E↑ Type II

APOE levels measured in type-2 AMI patients; comparative analysis of STEMI, NSTEMI, and type-2 AMI groups performed

T1DI 4.5 · 3 refs · Type-II-associated

Cystatin C↑ Type II

T1MI: 1.07 mg/L vs T2MI: 1.24 mg/L (p<0.05 after adjustment)

T1DI 16 · 11 refs · Shared / rises in both

All molecules — sortable scores

Direct T1-vs-T2 evidence only325 rows

Marker	Class	R	C	D	spec	A	E	T1DI ▼	PMIDs
CK-MBCKM	Shared / rises in both	67	50	+2	40.7	96	100	67.5	17
Cardiac troponin ITNNI3	Shared / rises in both	100	58	+2	65.7	96	78	62.0	13
Troponin TTNNT2	Shared / rises in both	100	60	—	40.0	96	85	57.1	27
Lactate	Indeterminate	67	48	—	19.1	96	86	49.2	18
PCSK9PCSK9	Shared / rises in both	67	50	—	16.7	72	95	39.9	6
LDL cholesterol	Shared / rises in both	67	53	—	13.4	84	82	39.1	7
B-type natriuretic peptideNPPB	Shared / rises in both	67	50	—	16.7	96	67	37.5	13
Growth differentiation factor 15GDF15	Shared / rises in both	100	78	—	22.0	84	73	37.4	22
von Willebrand factorVWF	Shared / rises in both	67	61	—	5.6	72	95	36.1	18
Neutrophil gelatinase-associated lipocalin (NGAL)LCN2	Shared / rises in both	100	56	—	44.0	68	73	35.7	20
Oxidized LDL	Shared / rises in both	67	67	—	0.0	82	86	35.3	16
Transforming Growth Factor-BetaTGFB1	Indeterminate	67	42	—	25.0	72	75	33.8	16
Cholesterol	Indeterminate	—	33	—	-18.3	84	95	32.6	4
Ischemia-modified albuminALB	Shared / rises in both	67	50	—	16.7	84	65	31.8	20
Immunoglobulin G	Shared / rises in both	67	58	—	8.4	68	86	31.7	9
Matrix Metalloproteinase-2MMP2	Shared / rises in both	67	50	—	16.7	72	75	31.5	20
Endothelin-1EDN1	Shared / rises in both	67	67	—	0.0	66	95	31.4	13
ADAMTS13ADAMTS13	Indeterminate	67	42	—	25.0	72	69	31.2	5
ST2IL1RL1	Shared / rises in both	67	56	—	11.1	84	66	30.7	8
Peroxisome proliferator-activated receptor	Shared / rises in both	67	61	—	5.6	68	80	28.7	20
C-X-C Chemokine Receptor Type 4CXCR4	Indeterminate	67	40	—	26.7	52	86	28.3	12
ERK1/2	Shared / rises in both	67	56	—	11.1	68	75	28.3	23
FerritinFTH1	Indeterminate	—	44	—	-29.4	84	95	28.2	11
Hemoglobin	Shared / rises in both	67	67	—	0.0	84	67	28.1	18
Prothrombin fragment 1+2F2	Shared / rises in both	67	56	—	11.1	84	60	28.0	12
SRC tyrosine kinaseSRC	Shared / rises in both	100	56	—	44.0	72	54	28.0	7
Toll-Like Receptor 4TLR4	Shared / rises in both	67	67	—	0.0	72	78	27.9	18
Albumin	Indeterminate	67	42	—	25.0	84	52	27.3	6
HDL	Indeterminate	67	—	—	16.7	84	55	27.0	2
High-mobility group box 1HMGB1	Shared / rises in both	67	67	—	0.0	72	75	27.0	19
P-selectinSELP	Shared / rises in both	67	67	—	0.0	72	75	27.0	21
FibronectinFN1	Shared / rises in both	67	67	—	0.0	72	75	27.0	19
FOXP3FOXP3	Indeterminate	67	47	—	20.0	52	86	26.8	14
Plasminogen activator inhibitor-1SERPINE1	Indeterminate	67	42	—	25.0	72	58	26.1	6
Apolipoprotein A-IAPOA1	Shared / rises in both	67	67	—	0.0	84	62	26.1	6
Platelet-derived growth factor	Shared / rises in both	67	60	—	7.0	68	71	25.8	17
ChymaseCMA1	Shared / rises in both	100	67	—	33.3	72	53	25.5	9
Cardiac Myosin-Binding Protein CMYBPC3	Shared / rises in both	67	67	+1	12.0	68	67	25.5	7
Glutathione peroxidaseGPX1	Shared / rises in both	67	67	—	0.0	68	75	25.5	22
Kidney injury molecule-1HAVCR1	Shared / rises in both	67	67	—	0.0	68	75	25.5	23
Methylglyoxal	Shared / rises in both	100	56	—	44.4	42	84	25.3	11
Interleukin-10IL10	Indeterminate	—	33	—	-18.3	72	86	25.3	11
Apolipoprotein BAPOB	Shared / rises in both	67	67	—	0.0	84	60	25.2	16
Matrix metalloproteinase-9MMP9	Shared / rises in both	67	76	—	-9.0	72	75	24.6	23
Interleukin-2IL2	Indeterminate	67	44	—	23.0	68	58	24.3	15
Interferon-GammaIFNG	Indeterminate	33	44	—	-11.1	72	75	24.0	14
HDL cholesterol	Indeterminate	33	33	—	0.0	84	57	23.9	5
CopeptinAVP	Shared / rises in both	67	58	+2	32.3	84	42	23.3	19
ATPase Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2ATP2A2	Shared / rises in both	67	67	—	0.0	52	86	22.4	14
Glutathione peroxidase 4GPX4	Shared / rises in both	67	57	—	10.0	68	60	22.4	20
Basic Fibroblast Growth FactorFGF2	Shared / rises in both	67	67	—	0.0	72	62	22.4	3
antithrombin IIISERPINC1	Type-II-associated	—	53	—	-38.3	84	86	22.3	13
E-selectinSELE	Shared / rises in both	67	61	—	6.0	72	58	22.1	15
Very-Low-Density Lipoprotein	Indeterminate	67	—	—	17.0	82	46	22.1	2
LPC (18:2)	Indeterminate	—	0	—	15.0	40	95	21.8	1
Phosphatidylinositol 3-kinase	Shared / rises in both	67	56	—	11.1	52	75	21.7	19
Angiotensin-Converting Enzyme 2ACE2	Indeterminate	67	44	—	22.2	68	52	21.6	20
Endothelial nitric oxide synthaseNOS3	Type-II-associated	—	52	—	-37.4	72	95	21.4	11
Thrombopoietin ReceptorMPL	Shared / rises in both	67	67	—	0.0	72	59	21.1	3
CD14CD14	Shared / rises in both	67	56	—	11.1	72	52	20.8	8