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Prothrombin fragment 1+2
Pathway / Coagulation & thrombus formation

Prothrombin fragment 1+2

F2protein

F1+2 release quantifies activated prothrombin conversion, reflecting the rate of thrombin generation and coagulation activation.

Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencehigh
RationaleDirect marker of factor Xa activity and thrombin generation in the tissue-factor-triggered cascade.
Also acts inMyocardial injury
Druggability
DruggableYes
Known drugs / candidates14
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000180210

Type I vs Type II discrimination

ScoresShared / rises in both
R — rupture / Type-I
67
C — confounder / Type-II
56
A — assay feasibility
84
E — evidence strength
60
T1DI (composite)
28
Specificity differential (R−C)+11.1
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
3hypovolemia / dehydrationn/a
4tachyarrhythmiamag 1
5hypoxemia / respiratory failuren/a
6hypertensive emergencymag 2
7high-demand / peri-operative stressn/a
Coverage: 3/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 12 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Platelet-poor plasma
Collection tube
Sodium citrate 3.2% (light blue-top)
Method / principle
Clotting assay (PT-based factor II) or calibrated automated thrombography
Reagent / substrate
Thromboplastin / fluorogenic thrombin substrate + tissue factor trigger
Platform
Coagulation analyzer / CAT fluorometer
Turnaround · availability
Routine–research · Clinical (factor II); research (thrombin generation)

Human genetic evidence

0.327
Open Targets association (acute_MI)

Literature evidence(53)